1. Autism-like behavior caused by deletion of vaccinia-related kinase ...
However, the neuronal function of VRK3 is still unknown despite its etiological potential in human autism spectrum disorder (ASD). ... H.G. Ryu performed EM image ...
Kang et al. showed that reduced vaccinia-related kinase 3 (VRK3) expression affects synaptic structure and function and results in cognitive dysfunction and autism-like behaviors in mice. TrkB stimulation reverses the altered synaptic properties and ...
2. [EPUB] Gestational hypothyroxinemia induces ASD-like phenotypes in behavior ...
1 mei 2024 · ... autistic traits in behavior (17, 18). Autism spectrum disorder (ASD) is defined as a sex-biased neurodevelopmental disorder (referring to ...
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3. Comparison of SHANK3 deficiency in animal models - APA PsycNet
16 nov 2021 · ... Abel, T. (2019). Home-cage hypoactivity in ... Syndrome and autism spectrum disorder. ... Ryu, J., Woodworth, M. A., Kidd, F. L., Sung ...
4. Altered TAOK2 activity causes autism-related neurodevelopmental ...
21 feb 2018 · A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic ... Hung AY, Futai K, Sala C, Valtschanoff JG, Ryu J, Woodworth ...
Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to NDDs is unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and knockout (KO) mice and found gene dosage-dependent impairments in cognition, anxiety, and social interaction. Taok2 Het and KO mice also have dosage-dependent abnormalities in brain size and neural connectivity in multiple regions, deficits in cortical layering, dendrite and synapse formation, and reduced excitatory neurotransmission. Whole-genome and -exome sequencing of ASD families identified three de novo mutations in TAOK2 and functional analysis in mice and human cells revealed that all the mutations impair protein stability, but they differentially impact kinase activity, dendrite growth, and spine/synapse development. Mechanistically, loss of Taok2 activity causes a reduction in RhoA activation, and pharmacological enhancement of RhoA activity rescues synaptic phenotypes. Together, these data provide evidence that TAOK2 is a neurodevelopmental disorder risk gene and identify RhoA signaling as a mediator of TAOK2-dependent synaptic development.
5. The Emerging Role of Flavonoids in Autism Spectrum Disorder - MDPI
17 mei 2023 · ... autism” OR “autism spectrum disorder” OR “autistic”. ... Kang, M.S.; Choi, T.Y.; Ryu, H.G.; Lee, D ... Abel, T.; Bauman, M.D.; Brodkin, E.S. ...
Although autism spectrum disorder (ASD) is a multifaceted neurodevelopmental syndrome, accumulating evidence indicates that oxidative stress and inflammation are common features of ASD. Flavonoids, one of the largest and best-investigated classes of plant-derived compounds, are known to exert antioxidant, anti-inflammatory, and neuroprotective effects. This review used a systematic search process to assess the available evidence on the effect of flavonoids on ASD. A comprehensive literature search was carried out in PubMed, Scopus, and Web of Science databases following the PRISMA guidelines. A total of 17 preclinical studies and 4 clinical investigations met our inclusion criteria and were included in the final review. Most findings from animal studies suggest that treatment with flavonoids improves oxidative stress parameters, reduces inflammatory mediators, and promotes pro-neurogenic effects. These studies also showed that flavonoids ameliorate the core symptoms of ASD, such as social deficits, repetitive behavior, learning and memory impairments, and motor coordination. However, there are no randomized placebo-controlled trials that support the clinical efficacy of flavonoids in ASD. We only found open-label studies and case reports/series, using only two flavonoids such as luteolin and quercetin. These preliminary clinical studies indicate that flavonoid administration may improve specific behavioral symptoms of ASD. Overall, this review is the first one to systematical...
6. Genetic Causes and Modifiers of Autism Spectrum Disorder - Frontiers
Ferri, S. L., Abel, T., and Brodkin, E. S. (2018). Sex differences in autism spectrum disorder: a review. Curr. Psychiatry Rep. 20:9. doi: 10.1007/s11920 ...
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental disorders, affecting an estimated 1 in 59 children. ASD is highly genetically ...
7. Multimodal annotation tool for challenging behaviors in people ...
Simulating Behaviors of Children with Autism Spectrum Disorders Through Reversal of the Autism Diagnosis Process ... Chong PAbel ... Kim SJo ERyu MCha IKim YYoo H ...
research-article
8. Altered behavior, brain structure, and neurometabolites in a rat model of ...
27 mrt 2023 · Silverman JL, Thurm A, Ethridge SB, Soller MM, Petkova SP, Abel T, et al. Reconsidering animal models used to study autism spectrum disorder: ...
Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD). Importantly, a clinically relevant connection exists between inflammation and metabolic stress that can result in aberrant cytokine signaling and autoimmunity. In this study we examined the potential for maternal autoantibodies (aAbs) to disrupt metabolic signaling and induce neuroanatomical changes in the brains of exposed offspring. To accomplish this, we developed a model of maternal aAb exposure in rats based on the clinical phenomenon of maternal autoantibody-related ASD (MAR-ASD). Following confirmation of aAb production in rat dams and antigen-specific immunoglobulin G (IgG) transfer to offspring, we assessed offspring behavior and brain structure longitudinally. MAR-ASD rat offspring displayed a reduction in pup ultrasonic vocalizations and a pronounced deficit in social play behavior when allowed to freely interact with a novel partner. Additionally, longitudinal in vivo structural magnetic resonance imaging (sMRI) at postnatal day 30 (PND30) and PND70, conducted in a separate cohort of animals, revealed sex-specific differences in total and regional brain volume. Treatment-specific effects by region appeared to converge on midbrain and cerebellar structures in MAR-ASD offspring. Simultaneously, in vivo 1H magnetic resonance spectroscopy (1H-MRS) data were collected to examine brain metabolite levels in the medial prefrontal cortex. Results showed that MAR-ASD offspring displa...
9. Min Goo LEE - Google Scholar
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021. 13364*, 2021. Autistic-like social behaviour in ...
Department of Pharmacology, Yonsei University College of Medicine - 引用: 25,649 件 - Membrane Transport - Pharmacogenomics
10. [PDF] Autism-like behavior caused by deletion of vaccinia - CORE
12 sep 2017 · Abel, and E. Klann. 2012. Reversal of impaired hippocampal long-term potentiation and contextual fear memory deficits in. Angelman syndrome ...
